IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis

An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Low-dose IL-2 therapy was shown to restore Treg homeostasis in patients with active SLE and its clinical e...

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Published in:Cells
Main Authors: Rose, Angelika, von Spee-Mayer, Caroline, Kloke, Lutz, Wu, Kaiyin, Kühl, Anja, Enghard, Philipp, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela, Humrich, Jens Y.
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829607/
https://ncbi.nlm.nih.gov/pubmed/31614462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101234
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