Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In the (NZBxNZW) F(1) mouse model of lupus, we found that CD4(+)Foxp3(+) Treg failed to maintain a competitive pool size in the peripheral lymphoid organs resulting in a p...

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Detalhes bibliográficos
Main Authors: Humrich, Jens Y., Morbach, Henner, Undeutsch, Reinmar, Enghard, Philipp, Rosenberger, Stefan, Weigert, Olivia, Kloke, Lutz, Heimann, Juliane, Gaber, Timo, Brandenburg, Susan, Scheffold, Alexander, Huehn, Jochen, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806746/
https://ncbi.nlm.nih.gov/pubmed/20018660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903158107
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