Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation

Myosin motors in the thick filament of resting striated (skeletal and cardiac) muscle are trapped in an OFF state, in which the motors are packed in helical tracks on the filament surface, inhibiting their interactions with actin and utilization of ATP. To investigate the structural changes induced...

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Bibliografske podrobnosti
izdano v:J Gen Physiol
Main Authors: Caremani, Marco, Brunello, Elisabetta, Linari, Marco, Fusi, Luca, Irving, Thomas C., Gore, David, Piazzesi, Gabriella, Irving, Malcolm, Lombardi, Vincenzo, Reconditi, Massimo
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829559/
https://ncbi.nlm.nih.gov/pubmed/31554652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912424
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