TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats

Hyperglycemia and hyperinsulinemia activate the proliferative potential of hepatic stellate cells (HSCs) and promote hepatic fibrosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, antidiabetic agents, reportedly inhibit the HSC proliferation. Additionally, Takeda G protein-coupled receptor 5 (TGR5) ag...

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Publicado en:Cells
Autores principales: Kaya, Daisuke, Kaji, Kosuke, Tsuji, Yuki, Yamashita, Satoko, Kitagawa, Koh, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829474/
https://ncbi.nlm.nih.gov/pubmed/31561561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101153
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