TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats

Hyperglycemia and hyperinsulinemia activate the proliferative potential of hepatic stellate cells (HSCs) and promote hepatic fibrosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, antidiabetic agents, reportedly inhibit the HSC proliferation. Additionally, Takeda G protein-coupled receptor 5 (TGR5) ag...

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發表在:Cells
Main Authors: Kaya, Daisuke, Kaji, Kosuke, Tsuji, Yuki, Yamashita, Satoko, Kitagawa, Koh, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi
格式: Artigo
語言:Inglês
出版: MDPI 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829474/
https://ncbi.nlm.nih.gov/pubmed/31561561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101153
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