Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis

Despite the use of various pharmacotherapeutic strategies, fibrosis due to nonalcoholic steatohepatitis (NASH) remains an unsatisfied clinical issue. We investigated the effect of sevelamer, a hydrophilic bile acid sequestrant, on hepatic fibrosis in a murine NASH model. Male C57BL/6J mice were fed...

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Detalhes bibliográficos
Publicado no:Microorganisms
Main Authors: Tsuji, Yuki, Kaji, Kosuke, Kitade, Mitsuteru, Kaya, Daisuke, Kitagawa, Koh, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Namisaki, Tadashi, Moriya, Kei, Akahane, Takemi, Yoshiji, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357162/
https://ncbi.nlm.nih.gov/pubmed/32575352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8060925
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