Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells

Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial–mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the a...

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Udgivet i:Cells
Main Authors: Olea-Flores, Monserrat, Zuñiga-Eulogio, Miriam, Tacuba-Saavedra, Arvey, Bueno-Salgado, Magdalena, Sánchez-Carvajal, Andrea, Vargas-Santiago, Yovani, Mendoza-Catalán, Miguel A., Pérez Salazar, Eduardo, García-Hernández, Alejandra, Padilla-Benavides, Teresita, Navarro-Tito, Napoleón
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829404/
https://ncbi.nlm.nih.gov/pubmed/31554180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101133
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