The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma

The aim of the present study is to investigate the effects of canagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, on non-alcoholic steatohepatitis (NASH) and NASH-related hepatocellular carcinoma (HCC) in a mouse model of diabetes and NASH-HCC. First, mice aged five weeks w...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Jojima, Teruo, Wakamatsu, Sho, Kase, Masato, Iijima, Toshie, Maejima, Yuko, Shimomura, Kenju, Kogai, Takahiko, Tomaru, Takuya, Usui, Isao, Aso, Yoshimasa
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829338/
https://ncbi.nlm.nih.gov/pubmed/31652578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20205237
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