Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges

Tauopathy is a class of a neurodegenerative disorder linked with tau hyperphosphorylation, proteolysis, and aggregation. Tau can be subjected to proteolysis upon calpain activation in Alzheimer disease (AD), and traumatic brain injury (TBI). We and others have extensively researched calpain-mediated...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Yadikar, Hamad, Johnson, Connor, Pafundi, Niko, Mouhawasse, Edwin, Nguyen, Lynn, Torres, Isabel, Kurup, Milin, Yang, Zhihui, Kobeissy, Firas, Yost, Richard, Wang, Kevin K.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829287/
https://ncbi.nlm.nih.gov/pubmed/31640160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20205213
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