Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases

INTRODUCTION: Sialic acids are important contributors to the polyanionic component of the glomerular filtration barrier, which regulates permeability selectivity. Pathologic glomerular hyposialylation, associated with podocyte effacement, has been implicated in human and mouse glomerulopathies. Oral...

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Detalhes bibliográficos
Publicado no:Kidney Int Rep
Main Authors: Huizing, Marjan, Yardeni, Tal, Fuentes, Federico, Malicdan, May C.V., Leoyklang, Petcharat, Volkov, Alexander, Dekel, Benjamin, Brede, Emily, Blake, Jodi, Powell, Alva, Chatrathi, Harish, Anikster, Yair, Carrillo, Nuria, Gahl, William A., Kopp, Jeffrey B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829193/
https://ncbi.nlm.nih.gov/pubmed/31701055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ekir.2019.06.012
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