Identification, Tissue Distribution and Molecular Modeling of Novel Human Isoforms of the Key Enzyme in Sialic Acid Synthesis, UDP-GlcNAc 2-epimerase/ManNAc Kinase()

UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) catalyzes the first two committed steps in sialic acid synthesis. In addition to the previously described 3 human GNE isoforms (hGNE1- hGNE3), our database and PCR analysis yielded an additional 5 human isoforms (hGNE4- hGNE8). hGNE1 is the ubiquitously exp...

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Detalhes bibliográficos
Main Authors: Yardeni, Tal, Choekyi, Tsering, Jacobs, Katherine, Ciccone, Carla, Patzel, Katherine, Anikster, Yair, Gahl, William A., Kurochkina, Natalya, Huizing, Marjan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192532/
https://ncbi.nlm.nih.gov/pubmed/21910480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201050u
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