Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice

We reported previously that adult (HRAS(−/−); NRAS(−/−)) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains...

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Publicado en:Cell Death Dis
Main Authors: Fuentes-Mateos, Rocío, Jimeno, David, Gómez, Carmela, Calzada, Nuria, Fernández-Medarde, Alberto, Santos, Eugenio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828777/
https://ncbi.nlm.nih.gov/pubmed/31685810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2075-2
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