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α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP(3) receptor
Emerging evidence implicates α-synuclein oligomers as potential culprits in the pathogenesis of Lewy body disease (LBD). Soluble oligomeric α-synuclein accumulation in cytoplasm is believed to modify neuronal activities and intraneural Ca(2+) dynamics, which augment the metabolic burden in central n...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6828767/ https://ncbi.nlm.nih.gov/pubmed/31685859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52135-3 |
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