A novel small-molecule inhibitor of trefoil factor 3 (TFF3) potentiates MEK1/2 inhibition in lung adenocarcinoma

TFF3 has been identified as a novel biomarker to distinguish between lung adenocarcinoma (ADC) and lung squamous-cell carcinoma (SCC). Herein, we determined the oncogenic functions of TFF3 and demonstrated the potential of pharmacological inhibition of TFF3 in lung ADC using a novel small-molecule i...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Zhang, Mengyi, Wang, Baocheng, Chong, Qing-Yun, Pandey, Vijay, Guo, Zhirong, Chen, Ru-Mei, Wang, Lingzhi, Wang, Yanxin, Ma, Lan, Kumar, Alan P., Zhu, Tao, Wu, Zheng-Sheng, Yin, Zhinan, Basappa, Goh, Boon-Cher, Lobie, Peter E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828705/
https://ncbi.nlm.nih.gov/pubmed/31685806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0173-8
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