Autocrine TGFβ is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment

Transforming growth factor β (TGFβ) is an effector of immune suppression and contributes to a permissive tumor microenvironment that compromises effective immunotherapy. We identified a correlation between TGFB1 and genes expressed by myeloid cells, but not granulocytes, in TCGA lung adenocarcinoma...

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Pubblicato in:Cancer Immunol Res
Autori principali: Gonzalez-Junca, Alba, Driscoll, Kyla E., Pellicciotta, Ilenia, Du, Shisuo, Lo, Chen Hao, Roy, Ritu, Parry, Renate, Tenvooren, Iliana, Marquez, Diana M., Spitzer, Matthew H., Barcellos-Hoff, Mary Helen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828175/
https://ncbi.nlm.nih.gov/pubmed/30538091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0310
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