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A Novel Mutation in an NPXY Motif of β Integrin Reveals Phenotypes Similar to him-4/hemicentin

Integrin, an αβ heterodimeric cell surface receptor for the extracellular matrix (ECM), carries two tyrosine phosphorylation motifs in the cytoplasmic tail of the β subunit. NPXY (Asn-Pro-x-Tyr) is a conserved tyrosine phosphorylation motif that binds to the phospho-tyrosine binding (PTB) domain. We...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Qiu, Zhongqiang, Sheesley, Peter, Ahn, Jeong H., Yu, Eun-Jeong, Lee, Myeongwoo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827421/
https://ncbi.nlm.nih.gov/pubmed/31720287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00247
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