Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif

Kindlin-3, a 75-kDa protein, has been shown to be critical for hemostasis, immunity, and bone metabolism via its role in integrin activation. The Kindlin family is hallmarked by a FERM domain comprised of F1, F2, and F3 subdomains together with an N-terminal F0 domain and a pleckstrin homology domai...

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Detalhes bibliográficos
Main Authors: Yates, Luke A., Füzéry, Anna K., Bonet, Roman, Campbell, Iain D., Gilbert, Robert J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488048/
https://ncbi.nlm.nih.gov/pubmed/22989875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415208
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