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Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters

A methyl group on an arene, despite its small size, can have a profound influence on biologically active molecules. Typical methods to form a methylarene involve strong nucleophiles or strong and often toxic electrophiles. We report a strategy for a new, highly efficient, copper and iodide co-cataly...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Chem Soc
Egile Nagusiak: He, Zhi-Tao, Li, Haoquan, Haydl, Alexander M., Whiteker, Gregory T., Hartwig, John F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827333/
https://ncbi.nlm.nih.gov/pubmed/30419749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10076
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