Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

Ligand-dependent differences in the regulation and internalization of the μ-opioid receptor (MOR) have been linked to the severity of adverse effects that limit opiate use in pain management. MOR activation by morphine or [d-Ala(2),N-MePhe(4), Gly-ol]enkephalin (DAMGO) causes differences in spatiote...

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Foilsithe in:J Biol Chem
Main Authors: Civciristov, Srgjan, Huang, Cheng, Liu, Bonan, Marquez, Elsa A., Gondin, Arisbel B., Schittenhelm, Ralf B., Ellisdon, Andrew M., Canals, Meritxell, Halls, Michelle L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2019
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827304/
https://ncbi.nlm.nih.gov/pubmed/31515267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008685
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