Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection

Insect-borne flaviviruses produce a 300–500–base long noncoding RNA, termed subgenomic flavivirus RNA (sfRNA), by stalling the cellular 5′–3′-exoribonuclease 1 (XRN1) via structures located in their 3′ UTRs. In this study, we demonstrate that sfRNA production by Zika virus represses XRN1 analogous t...

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Vydáno v:J Biol Chem
Hlavní autoři: Michalski, Daniel, Ontiveros, J. Gustavo, Russo, Joseph, Charley, Phillida A., Anderson, John R., Heck, Adam M., Geiss, Brian J., Wilusz, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827284/
https://ncbi.nlm.nih.gov/pubmed/31519749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009129
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