Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

The formation of the adduct between the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and glutathione, which leads to the generation of 3-glutathionyl-4-hydroxynonane (GSHNE), is one of the main routes of HNE detoxification. The aldo-keto reductase AKR1B1 is involved in the reduction of the a...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Balestri, Francesco, Barracco, Vito, Renzone, Giovanni, Tuccinardi, Tiziano, Pomelli, Christian Silvio, Cappiello, Mario, Lessi, Marco, Rotondo, Rossella, Bellina, Fabio, Scaloni, Andrea, Mura, Umberto, Del Corso, Antonella, Moschini, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827081/
https://ncbi.nlm.nih.gov/pubmed/31652566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8100502
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