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Sterol 12α-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15

Sterol 12α-hydroxylase (CYP8B1) is required for the synthesis of cholic acid in the classic bile acid synthesis pathway and plays a role in dyslipidemia and insulin resistance. However, the mechanism of the involvement of Cyp8b1 in dyslipidemia and insulin resistance is not known. CYP8B1 mRNA and pr...

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Bibliografiska uppgifter
I publikationen:Gene Expr
Huvudupphovsmän: Pathak, Preeti, Chiang, John Y. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cognizant Communication Corporation 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827038/
https://ncbi.nlm.nih.gov/pubmed/30890204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/105221619X15529371970455
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