Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts

Somatic mutations are critical for cancer development and may play a role in age‐related functional decline. Here, we used deep sequencing to analyze the prevalence of somatic mutations during in vitro cell aging. Primary dermal fibroblasts from healthy subjects of young and advanced age, from Hutch...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging Cell
Prif Awduron: Narisu, Narisu, Rothwell, Rebecca, Vrtačnik, Peter, Rodríguez, Sofía, Didion, John, Zöllner, Sebastian, Erdos, Michael R., Collins, Francis S., Eriksson, Maria
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826141/
https://ncbi.nlm.nih.gov/pubmed/31385397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13010
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