Target deconvolution of a multikinase inhibitor with anti-metastatic properties identifies TAOK3 as a key contributor to a cancer stem cell-like phenotype

Pancreatic cancer remains an incurable condition. Its progression is driven, in part, by subsets of cancer cells that evade the cytotoxic effects of conventional chemotherapies. These cells are often low-cycling, multi-drug resistant, and adopt a stem cell-like phenotype consistent with the concept...

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Udgivet i:Mol Cancer Ther
Main Authors: Bian, Yansong, Teper, Yaroslav, Griner, Lesley A. Mathews, Aiken, Taylor J., Shukla, Vivek, Guha, Rajarshi, Shinn, Paul, Xin, Hong-Wu, Pflicke, Holger, Powers, Astin S., Li, Dandan, Jiang, Jian-kang, Patel, Paresma, Rogers, Steven A., Aubé, Jeffrey, Ferrer, Marc, Thomas, Craig J, Rudloff, Udo
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825557/
https://ncbi.nlm.nih.gov/pubmed/31395684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1011
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