Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion

The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies based on individual tumor profiles are necessary to...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sorber, Rebecca, Teper, Yaroslav, Abisoye-Ogunniyan, Abisola, Waterfall, Joshua J., Davis, Sean, Killian, J. Keith, Pineda, Marbin, Ray, Satyajit, McCord, Matt R., Pflicke, Holger, Burkett, Sandra Sczerba, Meltzer, Paul S., Rudloff, Udo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786220/
https://ncbi.nlm.nih.gov/pubmed/26962861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149833
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