The novel small molecule SR18662 efficiently inhibits the growth of colorectal cancer in vitro and in vivo.

Krüppel-like factor 5 (KLF5), a member of the SP/KLF family of zinc finger transcription factors, is overexpressed in human colorectal cancer specimens and this overabundance is associated with aggressive cancer development and progression. We demonstrated that mice haploinsufficient for Klf5 had re...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kim, Julie, Wang, Chao, de Sabando, Ainara Ruiz, Cole, Hannah L., Huang, Timothy J., Yang, Jie, Bannister, Thomas D., Yang, Vincent W., Bialkowska, Agnieszka B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825545/
https://ncbi.nlm.nih.gov/pubmed/31358661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1366
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