The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma

PURPOSE: EGFR exon 19 deletion (Ex19Del) mutations account for ~60% of lung cancer-associated EGFR mutations and include a heterogeneous group of mutations. Although they are associated with benefit from tyrosine kinase inhibitors (TKIs), the relative inhibitor sensitivity of individual Ex19Del muta...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Truini, Anna, Starrett, Jacqueline H., Stewart, Tyler, Ashtekar, Kumar, Walther, Zenta, Wurtz, Anna, Lu, David, Park, Jin H., DeVeaux, Michelle, Song, Xiaoling, Gettinger, Scott, Zelterman, Daniel, Lemmon, Mark A., Goldberg, Sarah B., Politi, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825535/
https://ncbi.nlm.nih.gov/pubmed/31182434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0780
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