Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy

BACKGROUND: NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5–10% of cases and are associated with significantly shorter survival rates. The present study aimed to investigate the biological impact of this mutation in MCL and its potential as a therapeutic target. ME...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Silkenstedt, Elisabeth, Arenas, Fabian, Colom-Sanmartí, Berta, Xargay-Torrent, Sílvia, Higashi, Morihiro, Giró, Ariadna, Rodriguez, Vanina, Fuentes, Patricia, Aulitzky, Walter E., van der Kuip, Heiko, Beà, Sílvia, Toribio, Maria L., Campo, Elias, López-Guerra, Mònica, Colomer, Dolors
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825347/
https://ncbi.nlm.nih.gov/pubmed/31676012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1458-7
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