A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor

An Australian estuarine isolate of Penicillium sp. MST-MF667 yielded 3 tetrapeptides named the bilaids with an unusual alternating LDLD chirality. Given their resemblance to known short peptide opioid agonists, we elucidated that they were weak (K(i) low micromolar) μ-opioid agonists, which led to t...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Dekan, Zoltan, Sianati, Setareh, Yousuf, Arsalan, Sutcliffe, Katy J., Gillis, Alexander, Mallet, Christophe, Singh, Paramjit, Jin, Aihua H., Wang, Anna M., Mohammadi, Sarasa A., Stewart, Michael, Ratnayake, Ranjala, Fontaine, Frank, Lacey, Ernest, Piggott, Andrew M., Du, Yan P., Canals, Meritxell, Sessions, Richard B., Kelly, Eamonn, Capon, Robert J., Alewood, Paul F., Christie, MacDonald J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825270/
https://ncbi.nlm.nih.gov/pubmed/31611414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908662116
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