CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation

Sympathetic activation of β-adrenoreceptors (β-AR) represents a hallmark in the development of heart failure (HF). However, little is known about the underlying mechanisms of gene regulation. In human ventricular myocardium from patients with end-stage HF, we found high levels of phosphorylated hist...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Saadatmand, Ali Reza, Sramek, Viviana, Weber, Silvio, Finke, Daniel, Dewenter, Matthias, Sticht, Carsten, Gretz, Norbert, Wüstemann, Till, Hagenmueller, Marco, Kuenzel, Stephan R., Meyer-Roxlau, Stefanie, Kramer, Martin, Sossalla, Samuel, Lehmann, Lorenz H., Kämmerer, Susanne, Backs, Johannes, El-Armouche, Ali
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825262/
https://ncbi.nlm.nih.gov/pubmed/31619570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816521116
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