CaMKII Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure

BACKGROUND: Considerable evidence suggests that CaMKII overactivity plays a crucial role in the pathophysiology of heart failure (HF), a condition characterized by excessive β-adrenoceptor (β-AR) stimulation. Recent studies indicate a significant crosstalk between β-AR signaling and CaMKII activatio...

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Publié dans:Circ Heart Fail
Auteurs principaux: Dewenter, Matthias, Neef, Stefan, Vettel, Christiane, Lämmle, Simon, Beushausen, Christina, Zelarayan, Laura C., Katz, Sylvia, von der Lieth, Albert, Meyer-Roxlau, Stefanie, Weber, Silvio, Wieland, T, Sossalla, Samuel, Backs, Johannes, Brown, Joan Heller, Maier, Lars S., El-Armouche, Ali
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479434/
https://ncbi.nlm.nih.gov/pubmed/28487342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.003840
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