TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia

Legionella pneumophila (Lp) is a flagellated, intracellular bacterium that can cause Legionnaires’ disease (LD). Lp activates multiple innate immune receptors, and TOLLIP dampens MyD88-dependent signaling and may influence susceptibility to LD. We evaluated the effect of TOLLIP on innate immunity, p...

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Pubblicato in:Mucosal Immunol
Autori principali: Shah, Javeed A., Emery, Robyn, Lee, Brian, Venkatasubramanian, Sambasivan, Simmons, Jason D., Brown, Melanie, Hung, Chi F., Prins, Jan M., Verbon, Annelies, Hawn, Thomas R., Skerrett, Shawn J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824992/
https://ncbi.nlm.nih.gov/pubmed/31462698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-019-0196-7
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