Two Novel GATA1 Mutations in Transient Abnormal Myelopoiesis of Thai Neonates with Down Syndrome

Children with Down syndrome (DS) are 150 times more likely to develop acute myeloid leukemia (ML-DS), compared with those without. One risk factor is transient abnormal myelopoiesis (TAM). Somatic truncating GATA1 mutations are found in most TAM patients and are markers for future ML-DS. We identifi...

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Vydáno v:J Pediatr Genet
Hlavní autoři: Chukua, Kanokporn, Netsawang, Chayanont, Padungthai, Kittipoom, Khetkham, Thanitchet, Chokevittaya, Piyaporn, Poonjearansilp, Onapinya, Prachuktum, Sariya, Kositamongkol, Sudatip, Techasatit, Wiliporn, Silapamongkolkul, Phakatip, Satayasai, Wallee, Pusongchai, Tasama, Surapolchai, Pacharapan, Rojnueangnit, Kitiwan
Médium: Artigo
Jazyk:Inglês
Vydáno: Georg Thieme Verlag KG 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824893/
https://ncbi.nlm.nih.gov/pubmed/31687255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0039-1696971
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