Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6

The termination of pre-mRNA splicing functions to discard suboptimal substrates, thereby enhancing fidelity, and to release excised introns in a manner coupled to spliceosome disassembly, thereby allowing recycling. The mechanism of termination, including the RNA target of the DEAH-box ATPase Prp43p...

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Publicat a:Genes Dev
Autors principals: Toroney, Rebecca, Nielsen, Klaus H., Staley, Jonathan P.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824469/
https://ncbi.nlm.nih.gov/pubmed/31558568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328294.119
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