Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling

Genome rearrangements that occur during evolution impose major challenges on regulatory mechanisms that rely on three-dimensional genome architecture. Here, we developed a scaffolding algorithm and generated chromosome-length assemblies from Hi-C data for studying genome topology in three distantly...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Renschler, Gina, Richard, Gautier, Valsecchi, Claudia Isabelle Keller, Toscano, Sarah, Arrigoni, Laura, Ramírez, Fidel, Akhtar, Asifa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2019
Konular:
Resource Methodology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824461/
https://ncbi.nlm.nih.gov/pubmed/31601616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328971.119
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