β(IV)-Spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis, and cardiac function

Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a critical step in the fibrotic response, although the precise...

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Pubblicato in:JCI Insight
Autori principali: Patel, Nehal J., Nassal, Drew M., Greer-Short, Amara D., Unudurthi, Sathya D., Scandling, Benjamin W., Gratz, Daniel, Xu, Xianyao, Kalyanasundaram, Anuradha, Fedorov, Vadim V., Accornero, Federica, Mohler, Peter J., Gooch, Keith J., Hund, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824442/
https://ncbi.nlm.nih.gov/pubmed/31550236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131046
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