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Ca(2+)/calmodulin kinase II–dependent regulation of β(IV)-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein β(IV)-spectrin as an important step in CF activation and cardiac fibrosis. Furthermore, los...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8294584/ https://ncbi.nlm.nih.gov/pubmed/34153319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100893 |
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