Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib

Infantile myofibromatosis (IM) is an aggressive neoplasm composed of myofibroblast-like cells in children. Although typically localized, it can also present as multifocal disease, which represents a challenge for effective treatment. IM has previously been linked to activating somatic and germline p...

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Publicado en:Cold Spring Harb Mol Case Stud
Main Authors: Hassan, Mohammed, Butler, Erin, Wilson, Raphael, Roy, Angshumoy, Zheng, Yanbin, Liem, Priscilla, Rakheja, Dinesh, Pavlick, Dean, Young, Lauren L., Rosenzweig, Mark, Erlich, Rachel, Ali, Siraj M., Leavey, Patrick J., Parsons, D. Williams, Skapek, Stephen X., Laetsch, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824247/
https://ncbi.nlm.nih.gov/pubmed/31645346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a004440
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