Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1α axis regulates ER stress during high-carbohydrate feeding

Stearoyl CoA desaturase 1 (SCD1) is a key enzyme in lipogenesis as it catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate (18:1n9) and palmitoleate (16:1n7) from saturated fatty acids (SFA), stearate (18:0) and palmitate (16:0), respectively. Studies on SCD1 deficiency in m...

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Vydáno v:Sci Rep
Hlavní autoři: Aljohani, Ahmed, Khan, Mohammad Imran, Syed, Deeba N., Abram, Bonneville, Lewis, Sarah, Neill, Lucas O’, Mukhtar, Hasan, Ntambi, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823547/
https://ncbi.nlm.nih.gov/pubmed/31673045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52339-7
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