Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α–FGF21 axis in mice

Increased carbohydrate consumption increases hepatic de novo lipogenesis, which has been linked to the development of chronic metabolic diseases, including obesity, hepatic steatosis, and insulin resistance. Stearoyl CoA desaturase 1 (SCD1) is a critical lipogenic enzyme that catalyzes the synthesis...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Aljohani, Ahmed, Khan, Mohammad Imran, Bonneville, Abram, Guo, Changan, Jeffery, Justin, O'Neill, Lucas, Syed, Deeba Nadeem, Lewis, Sarah A., Burhans, Maggie, Mukhtar, Hasan, Ntambi, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926457/
https://ncbi.nlm.nih.gov/pubmed/31690632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009868
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