Heparin and heparan sulfate proteoglycans promote HIV-1 p17 matrix protein oligomerization: computational, biochemical and biological implications

p17 matrix protein released by HIV+ cells interacts with leukocytes heparan sulfate proteoglycans (HSPGs), CXCR1 and CXCR2 exerting different cytokine-like activities that contribute to AIDS pathogenesis. Since the bioactive form of several cytokines is represented by dimers/oligomers and oligomeriz...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bugatti, Antonella, Paiardi, Giulia, Urbinati, Chiara, Chiodelli, Paola, Orro, Alessandro, Uggeri, Matteo, Milanesi, Luciano, Caruso, Arnaldo, Caccuri, Francesca, D’Ursi, Pasqualina, Rusnati, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823450/
https://ncbi.nlm.nih.gov/pubmed/31673058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52201-w
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