Molecular Interaction Studies of HIV-1 Matrix Protein p17 and Heparin: IDENTIFICATION OF THE HEPARIN-BINDING MOTIF OF p17 AS A TARGET FOR THE DEVELOPMENT OF MULTITARGET ANTAGONISTS

Once released by HIV(+) cells, p17 binds heparan sulfate proteoglycans (HSPGs) and CXCR1 on leukocytes causing their dysfunction. By exploiting an approach integrating computational modeling, site-directed mutagenesis of p17, chemical desulfation of heparin, and surface plasmon resonance, we charact...

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Detalhes bibliográficos
Main Authors: Bugatti, Antonella, Giagulli, Cinzia, Urbinati, Chiara, Caccuri, Francesca, Chiodelli, Paola, Oreste, Pasqua, Fiorentini, Simona, Orro, Alessandro, Milanesi, Luciano, D'Ursi, Pasqualina, Caruso, Arnaldo, Rusnati, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542999/
https://ncbi.nlm.nih.gov/pubmed/23166320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400077
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