Lack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers

Imrecoxib is a registered treatment for osteoarthritis pain symptoms in China. This study aims to assess the effect of imrecoxib on the pharmacodynamics and pharmacokinetics of warfarin. 12 healthy male volunteers with CYP2C9*3 AA and VKORC1 AA genotypes took a 5 mg dose of warfarin both alone and c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Yani, Zhang, Rui, Li, Zhongfang, Zhou, Jiali, Yang, Tingyu, Yang, Chunxiao, Huang, Xixi, Zhang, Yu, Shi, Shaojun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823368/
https://ncbi.nlm.nih.gov/pubmed/31673051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51755-z
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