The pharmacokinetics and pharmacodynamics of warfarin in combination with ambrisentan in healthy volunteers

AIMS: Ambrisentan is an oral, propanoic acid-based endothelin receptor antagonist often co-administered with warfarin to patients with pulmonary arterial hypertension. The aim of this study was to evaluate the potential for ambrisentan to affect warfarin pharmacokinetics and pharmacodynamics. METHOD...

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Hlavní autoři: Walker, Gennyne, Mandagere, Arun, Dufton, Christopher, Venitz, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2009
Témata:
Drug Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686069/
https://ncbi.nlm.nih.gov/pubmed/19552747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03384.x
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