MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity

Mitogen-activated protein kinase (MAPK) kinase (MEK) is an integral component of the RAS pathway and a therapeutic target in RAS-driven cancers. Although tumor responses to MEK inhibition are rarely durable, MEK inhibitors have shown substantial activity and durable tumor regressions when combined w...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Yarchoan, Mark, Mohan, Aditya A., Dennison, Lauren, Vithayathil, Teena, Ruggieri, Amanda, Lesinski, Gregory B., Armstrong, Todd D., Azad, Nilofer S., Jaffee, Elizabeth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822709/
https://ncbi.nlm.nih.gov/pubmed/31671149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224600
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