Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb–drug interaction. The present study, therefore, evaluated the effects of orally administered GRT on...

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Pubblicato in:Front Pharmacol
Autori principali: Patel, Oelfah, Muller, Christo J.F., Joubert, Elizabeth, Rosenkranz, Bernd, Taylor, Malcolm J.C., Louw, Johan, Awortwe, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822546/
https://ncbi.nlm.nih.gov/pubmed/31708777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01243
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