Molecular determinants for enzalutamide-induced transcription in prostate cancer

Enzalutamide, a second-generation androgen receptor (AR) antagonist, has demonstrated clinical benefit in men with prostate cancer. However, it only provides a temporary response and modest increase in survival, indicating a rapid evolution of resistance. Previous studies suggest that enzalutamide m...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Yuan, Fuwen, Hankey, William, Wu, Dayong, Wang, Hongyan, Somarelli, Jason, Armstrong, Andrew J, Huang, Jiaoti, Chen, Zhong, Wang, Qianben
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821169/
https://ncbi.nlm.nih.gov/pubmed/31501863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz790
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