Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats

Leucine can stimulate protein synthesis in skeletal muscle, and recent studies have shown an increase in leucine-related mitochondrial biogenesis and oxidative phosphorylation capacity in muscle cells. However, leucine-related effects in tumour tissues are still poorly understood. Thus, we described...

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Udgivet i:Sci Rep
Main Authors: Viana, Laís Rosa, Tobar, Natália, Busanello, Estela Natacha Brandt, Marques, Ana Carolina, de Oliveira, Andre Gustavo, Lima, Tanes I., Machado, Gabrielly, Castelucci, Bianca Gazieri, Ramos, Celso Dario, Brunetto, Sérgio Q, Silveira, Leonardo Reis, Vercesi, Anibal Eugenio, Consonni, Sílvio Roberto, Gomes-Marcondes, Maria Cristina Cintra
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820796/
https://ncbi.nlm.nih.gov/pubmed/31664147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52112-w
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