Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents

RATIONALE: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using probabilistic reversal learning (PRL) paradigms. OBJECTIVES: This study used computationa...

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Vydáno v:Psychopharmacology (Berl)
Hlavní autoři: Kanen, Jonathan W., Ersche, Karen D., Fineberg, Naomi A., Robbins, Trevor W., Cardinal, Rudolf N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2019
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820481/
https://ncbi.nlm.nih.gov/pubmed/31324936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-019-05325-w
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