Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and differen...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Li, Lili, Fan, Yichao, Huang, Xin, Luo, Jie, Zhong, Lan, Shu, Xing-sheng, Lu, Li, Xiang, Tingxiu, Chan, Anthony T.C., Yeo, Winnie, Chen, Ceshi, Chan, Wai Yee, Huganir, Richard L., Tao, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820368/
https://ncbi.nlm.nih.gov/pubmed/31654850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.007
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