Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and differen...

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Veröffentlicht in:iScience
Hauptverfasser: Li, Lili, Fan, Yichao, Huang, Xin, Luo, Jie, Zhong, Lan, Shu, Xing-sheng, Lu, Li, Xiang, Tingxiu, Chan, Anthony T.C., Yeo, Winnie, Chen, Ceshi, Chan, Wai Yee, Huganir, Richard L., Tao, Qian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820368/
https://ncbi.nlm.nih.gov/pubmed/31654850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.007
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