SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury

BACKGROUND: Hydrogen peroxide (H(2)O(2))-induced mitochondrial oxidative damage is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H(2)O(2) scavenger that protects cells from mitochondrial oxidative damage and apoptosis. However, the function of PRDX3 in intestina...

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Publicado no:Redox Biol
Main Authors: Wang, Zhanyu, Sun, Ruimin, Wang, Guangzhi, Chen, Zhao, Li, Yang, Zhao, Yan, Liu, Deshun, Zhao, Huanyu, Zhang, Feng, Yao, Jihong, Tian, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820261/
https://ncbi.nlm.nih.gov/pubmed/31655428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101343
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